Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents
نویسندگان
چکیده
منابع مشابه
Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents
Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been overcome in spite of decades of research. And yet defined chromatin targets have generally not been considered in the drug development process. Here we designed novel platinum-intercalator species to target a highly deformed DNA site near the n...
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در این پایان نامه، درهمتنیدگی بین یک سیستم نقطه کوانتومی دوگانه(مولکول نقطه کوانتومی) و میدان مورد مطالعه قرار گرفته است. از آنتروپی ون نیومن به عنوان ابزاری برای بررسی درهمتنیدگی بین اتم و میدان استفاده شده و تاثیر پارامترهای مختلف، نظیر تونل زنی(که توسط تغییر ولتاژ ایجاد می شود)، شدت میدان و نسبت دو گسیل خودبخودی بر رفتار درجه درهمتنیدگی سیستم بررسی شده اشت.با تغییر هر یک از این پارامترها، در...
15 صفحه اولEffect of Platinum Antitumor Agents on DMA and RNA Investigated by Terbium Fluorescence1
Terbium, a fluorescent probe, which fluoresces primarily with guanine and xanthine bases, has been used to investigate the interaction of platinum complexes with DNA and RNA. c/sDichlorodiammineplatinum(ll), a potent antitumor agent, pro duced a marked enhancement in fluorescence intensity when reacted with double-stranded DNA. This can be explained by the c/s-dichlorodiammineplatinum(ll) produ...
متن کاملEffect of platinum antitumor agents on DNA and RNA investigated by terbium fluorescence.
Terbium, a fluorescent probe, which fluoresces primarily with guanine and xanthine bases, has been used to investigate the interaction of platinum complexes with DNA and RNA. c/sDichlorodiammineplatinum(ll), a potent antitumor agent, pro duced a marked enhancement in fluorescence intensity when reacted with double-stranded DNA. This can be explained by the c/s-dichlorodiammineplatinum(ll) produ...
متن کاملStereochemical control of DNA biosynthesis.
Stereochemical control of DNA biosynthesis was studied using several DNA-synthesizing complexes containing, in each case, a single substitution of a 2'-deoxy-D-nucleotide residue by an enantiomeric L-nucleotide residue in a DNA chain (either in the primer or in the template) as well as 2'-deoxy-L-ribonucleoside 5'-triphosphates (L-dNTPs) as substrates. Three template-dependent DNA polymerases w...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkv356